About Gene List

PF3D7_0830700

Genome location: Pf3D7_08_v3:1,306,209..1,308,595(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (hyp9), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell
Component GO:0016021 integral component of membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.40 0.81
Trophozoite expressed 0.63 0.69
Schizont expressed 0.05 0.97
Gametocyte expressed 0.08 0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0830700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.215 | MFS: -3.481 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBD3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_149546

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 1 0
disruptive 0 0 0 0
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 0 1 0
disruptive 0 0 0 0
missense 0 0 0 0

PlasmoDB Total SNPs: 114

Non-coding: 104 | Synonymous: 5 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 218 | Molecular Weight (kDa): 25.086

UniProt ID(s): Q8IBD3

PDB ID(s): None

Isoelectric Point: 8.61

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12