Genome location: Pf3D7_08_v3:1,309,285..1,317,662(+)
Genome classification: Core
Product Description: surface-associated interspersed protein 8.2 (SURFIN 8.2)
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0044228 | host cell surface |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.27 | 0.88 |
| Trophozoite | possibly expressed | 0.25 | 0.87 |
| Schizont | not expressed | 0.25 | 0.85 |
| Gametocyte | not expressed | 0.70 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0830800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.313 | #Insertions: 8
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBD4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 45 | 51 | 34 | 77 |
| disruptive | 266 | 249 | 140 | 310 |
| missense | 229 | 220 | 125 | 253 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 53 | 86 | 46 | 81 |
| disruptive | 335 | 462 | 210 | 408 |
| missense | 272 | 378 | 169 | 313 |
PlasmoDB Total SNPs: 501
Non-coding: 86 | Synonymous: 140 | Nonsynonymous: 275 | Stop Codon: 0
Protein Length: 2049 | Molecular Weight (kDa): 248.481
UniProt ID(s): A0A348FV65, A0A348FV75, D9HNK4, D9HNM7, D9HNN0, D9HNN2, D9HNP9, D9HNQ0, D9HNR0, D9HNR8, Q8IBD4
PDB ID(s): None
Isoelectric Point: 5.12
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR024288 | Schizont-infected cell agglutination, C-terminal domain |
| PFam | PF12879 | Schizont-infected cell agglutination, C-terminal domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 15939796 | SURFIN is a polymorphic antigen expressed on Plasmodium falciparum merozoites andinfected erythrocytes. | Winter G, Kawai S, ..., Wahlgren M | 10.1084/jem.20041392 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |