PF3D7_0831100 (SURF8.1)

Genome location: Pf3D7_08_v3:1,324,597..1,331,626(+)

Genome classification: Core

Function and Localization

Product Description: surface-associated interspersed protein 8.1 (SURFIN 8.1)

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0009986	cell surface
Component	GO:0044228	host cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.06	0.97
Trophozoite	expressed	0.05	0.98
Schizont	possibly expressed	0.02	0.99
Gametocyte	possibly expressed	0.27	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0831100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.303 | #Insertions: 7

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4Z4

"Best" AlphaFill ligand hit: IMP (inosinic acid, Local RMSD=0.09) with 6M9M (Global RMSD=15.82)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134606

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	16	38	17	52
disruptive	99	255	99	238
missense	83	203	79	174

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	68	25	45
disruptive	159	409	124	227
missense	122	310	99	166

PlasmoDB Total SNPs: 577

Non-coding: 161 | Synonymous: 155 | Nonsynonymous: 246 | Stop Codon: 15

Protein Information

Protein Length: 1921 | Molecular Weight (kDa): 236.183

UniProt ID(s): A0A2H4THN3, A0A2H4THP7, A0A2H4THU3, A0A348FV60, A0A348FV64, A0A348FV70, A0A348FV74, C0H4Z4

PDB ID(s): None

Isoelectric Point: 5.1

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR024288	Schizont-infected cell agglutination, C-terminal domain
PFam	PF12879	Schizont-infected cell agglutination, C-terminal domain
Superfamily	N/A	N/A