PF3D7_0831200

Genome location: Pf3D7_08_v3:1,332,590..1,336,697(+)

Genome classification: Core

Function and Localization

Product Description: DnaJ protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	1.11	0.54
Trophozoite	no data	0.48	0.73
Schizont	no data	0.41	0.76
Gametocyte	no data	0.60	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0831200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.486 | #Insertions: 3

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1238200)

Relative Growth Rate: 0.78 ± 0.07
Confidence: 6.69

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4Z5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102152

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	16	52	27	58
disruptive	74	159	75	155
missense	45	136	64	128

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	29	88	34	52
disruptive	119	277	118	221
missense	75	222	95	150

PlasmoDB Total SNPs: 199

Non-coding: 84 | Synonymous: 65 | Nonsynonymous: 50 | Stop Codon: 0

Protein Information

Protein Length: 961 | Molecular Weight (kDa): 114.103

UniProt ID(s): C0H4Z5

PDB ID(s): None

Isoelectric Point: 9.17

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001623	DnaJ domain
InterPro	IPR018253	DnaJ domain, conserved site
InterPro	IPR019111	Plasmodium RESA, N-terminal
InterPro	IPR026894	DNAJ-containing protein, X-domain
InterPro	IPR036869	Chaperone J-domain superfamily
PFam	PF00226	DnaJ domain
PFam	PF09687	Plasmodium RESA, N-terminal
PFam	PF14308	DNAJ-containing protein, X-domain
Superfamily	SSF46565	Chaperone J-domain superfamily