About Gene List

PF3D7_0831200

Genome location: Pf3D7_08_v3:1,332,590..1,336,697(+)

Genome classification: Core

Function and Localization

Product Description: DnaJ protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 1.11 0.54
Trophozoite no data 0.48 0.73
Schizont no data 0.41 0.76
Gametocyte no data 0.60 0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0831200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.486 | #Insertions: 3

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1238200)

  • Relative Growth Rate: 0.78 ± 0.07
  • Confidence: 6.69

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4Z5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102152

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 16 52 27 58
disruptive 74 159 75 155
missense 45 136 64 128

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 29 88 34 52
disruptive 119 277 118 221
missense 75 222 95 150

PlasmoDB Total SNPs: 199

Non-coding: 84 | Synonymous: 65 | Nonsynonymous: 50 | Stop Codon: 0

Protein Information

Protein Length: 961 | Molecular Weight (kDa): 114.103

UniProt ID(s): C0H4Z5

PDB ID(s): None

Isoelectric Point: 9.17

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001623 DnaJ domain
InterPro IPR018253 DnaJ domain, conserved site
InterPro IPR019111 Plasmodium RESA, N-terminal
InterPro IPR026894 DNAJ-containing protein, X-domain
InterPro IPR036869 Chaperone J-domain superfamily
PFam PF00226 DnaJ domain
PFam PF09687 Plasmodium RESA, N-terminal
PFam PF14308 DNAJ-containing protein, X-domain
Superfamily SSF46565 Chaperone J-domain superfamily

Associated Publications

No associated publications