PF3D7_0831300 (GEXP13)

Genome location: Pf3D7_08_v3:1,337,791..1,342,328(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0043657	host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.11	0.95
Trophozoite	no data	0.51	0.72
Schizont	no data	0.08	0.95
Gametocyte	no data	1.26	0.40

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0831300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.529 | MFS: -2.522 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4Z6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_119672

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	27	8	34
disruptive	63	134	53	121
missense	56	109	44	104

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	45	32	23
disruptive	92	210	84	149
missense	77	168	70	105

PlasmoDB Total SNPs: 305

Non-coding: 114 | Synonymous: 84 | Nonsynonymous: 107 | Stop Codon: 0

Protein Information

Protein Length: 821 | Molecular Weight (kDa): 98.972

UniProt ID(s): C0H4Z6

PDB ID(s): None

Isoelectric Point: 4.09

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A