PF3D7_0831400

Genome location: Pf3D7_08_v3:1,343,563..1,345,903(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: MMRILYTNVFLFIAVLFCILSPGNNP

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0043657	host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.23	0.91
Trophozoite	no data	0.99	0.67
Schizont	no data	0.07	0.97
Gametocyte	no data	0.04	0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0831400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.969 | MFS: -0.655 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4Z7

"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=2.57) with 3R0Q (Global RMSD=20.94)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533706

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	5	3	9
disruptive	24	31	13	30
missense	18	30	11	28

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	8	7	15
disruptive	29	46	28	57
missense	23	39	26	43

PlasmoDB Total SNPs: 142

Non-coding: 101 | Synonymous: 14 | Nonsynonymous: 27 | Stop Codon: 0

Protein Information

Protein Length: 302 | Molecular Weight (kDa): 36.413

UniProt ID(s): C0H4Z7

PDB ID(s): None

Isoelectric Point: 5.98

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A