PF3D7_0831500

Genome location: Pf3D7_08_v3:1,352,286..1,356,302(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHIST), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0043657	host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	1.06	0.54
Trophozoite	no data	0.57	0.72
Schizont	no data	0.15	0.91
Gametocyte	no data	0.09	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0831500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.795 | MFS: -3.036 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZW02

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110760

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 229

Non-coding: 207 | Synonymous: 12 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 335 | Molecular Weight (kDa): 39.098

UniProt ID(s): A0A143ZW02

PDB ID(s): None

Isoelectric Point: 8.84

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006526	Exported protein, PHISTa/b/c, conserved domain, Plasmodium
InterPro	IPR019111	Plasmodium RESA, N-terminal
PFam	PF09687	Plasmodium RESA, N-terminal
Superfamily	N/A	N/A