PF3D7_0832200

Genome location: Pf3D7_08_v3:1,391,454..1,394,200(+)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: Plasmodium exported protein (PHISTa-like), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0044164	host cell cytosol

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	nd	nd
Trophozoite	no data	nd	nd
Schizont	no data	nd	nd
Gametocyte	no data	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0832200.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.494 | MFS: -2.573 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZWT9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110760

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 203

Non-coding: 117 | Synonymous: 22 | Nonsynonymous: 55 | Stop Codon: 9

Protein Information

Protein Length: 286 | Molecular Weight (kDa): 33.544

UniProt ID(s): A0A143ZWT9

PDB ID(s): None

Isoelectric Point: 4.54

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006526	Exported protein, PHISTa/b/c, conserved domain, Plasmodium
InterPro	IPR019111	Plasmodium RESA, N-terminal
PFam	PF09687	Plasmodium RESA, N-terminal
Superfamily	N/A	N/A