Genome location: Pf3D7_08_v3:1,420,818..1,422,077(-)
Genome classification: SubtelomericHypervariable
Product Description: rifin
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0020002 | host cell plasma membrane |
| Component | GO:0020003 | symbiont-containing vacuole |
| Process | GO:0020033 | antigenic variation |
| Process | GO:0020035 | cytoadherence to microvasculature, mediated by symbiont protein |
| Process | GO:0020013 | modulation by symbiont of host erythrocyte aggregation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.00 | 1.00 |
| Trophozoite | no data | 0.00 | 1.00 |
| Schizont | no data | 0.00 | 1.00 |
| Gametocyte | no data | nd | 1.00 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0833100
Resistome Missense Mutations: L100F, E101D, T301A, T303A
Resistome Compounds with Missense Mutations: AN13762, Halofuginone
Resistome # Samples with Disruptive Mutations: 3 (3 missense, 2 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.754 | MFS: -2.194 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZWJ4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 564
Non-coding: 13 | Synonymous: 123 | Nonsynonymous: 427 | Stop Codon: 1
Protein Length: 368 | Molecular Weight (kDa): 41.188
UniProt ID(s): A0A143ZWJ4
PDB ID(s): None
Isoelectric Point: 8.52
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006373 | Variant surface antigen Rifin |
| PFam | PF02009 | Variant surface antigen Rifin |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10430943 | Rifins: a second family of clonally variant proteins expressed on the surface ofred cells infected with Plasmodium falciparum. | Kyes SA, Rowe JA, Kriek N, Newbold CI | 10.1073/pnas.96.16.9333 |
| 25751816 | RIFINs are adhesins implicated in severe Plasmodium falciparum malaria. | Goel S, Palmkvist M, ..., Wahlgren M | 10.1038/nm.3812 |