PF3D7_0833500 (VAR)

Genome location: Pf3D7_08_v3:1,435,794..1,443,449(-)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: erythrocyte membrane protein 1, PfEMP1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.04	0.98
Trophozoite	no data	0.06	0.96
Schizont	no data	0.11	0.92
Gametocyte	no data	0.05	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0833500

Resistome Missense Mutations: D704E, V1783L, F1784L, K1790I, A1808T

Resistome Compounds with Missense Mutations: AN13762, DDD01061024, MMV019313

Resistome # Samples with Disruptive Mutations: 14 (4 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: N/A

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZZY8

"Best" AlphaFill ligand hit: 3PO (triphosphate, Local RMSD=1.65) with 5MZA (Global RMSD=6.33)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104345

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 2643

Non-coding: 332 | Synonymous: 627 | Nonsynonymous: 1676 | Stop Codon: 8

Protein Information

Protein Length: 2269 | Molecular Weight (kDa): 255.775

UniProt ID(s): A0A143ZZY8, A0A5P1A034

PDB ID(s): None

Isoelectric Point: 5.23

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004258	Duffy-binding-like domain
InterPro	IPR008602	Duffy-antigen binding
InterPro	IPR029210	Plasmodium falciparum erythrocyte membrane protein-1, N-terminal segment
InterPro	IPR029211	Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment
InterPro	IPR041480	Cysteine-rich interdomain region 1 gamma
PFam	PF03011	Duffy-binding-like domain
PFam	PF05424	Duffy-antigen binding
PFam	PF15445	Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment
PFam	PF15447	Plasmodium falciparum erythrocyte membrane protein-1, N-terminal segment
PFam	PF18562	Cysteine-rich interdomain region 1 gamma
Superfamily	SSF140924	N/A