PF3D7_0900300 (RIF)

Genome location: Pf3D7_09_v3:33,553..34,795(-)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: rifin

SignalP Peptide: MKLNYTKILLFFFPLNILLTSYHVHS

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.00	1.00
Trophozoite	possibly expressed	0.00	1.00
Schizont	possibly expressed	0.00	1.00
Gametocyte	possibly expressed	0.00	1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0900300

Resistome Missense Mutations: G118V, A147S, K150E, A161T, D162A, N169D, N169K, S170A, G172R, K223T, Q315H

Resistome Compounds with Missense Mutations: AN13762, AN13956, DDD01061024, Halofuginone

Resistome # Samples with Disruptive Mutations: 10 (10 missense, 7 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.34 | MFS: -2.394 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3E3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100719

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 636

Non-coding: 75 | Synonymous: 100 | Nonsynonymous: 460 | Stop Codon: 1

Protein Information

Protein Length: 359 | Molecular Weight (kDa): 40.078

UniProt ID(s): Q2XR93, Q8I3E3

PDB ID(s): None

Isoelectric Point: 10.11

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006373	Variant surface antigen Rifin
PFam	PF02009	Variant surface antigen Rifin
Superfamily	N/A	N/A