About Gene List

PF3D7_0900900

Genome location: Pf3D7_09_v3:55,074..56,081(-)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: stevor

SignalP Peptide: MKMYNLKMLLFTFLINTLA

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Process GO:0020013 modulation by symbiont of host erythrocyte aggregation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed nd 1.00
Trophozoite possibly expressed 0.00 1.00
Schizont not expressed nd 1.00
Gametocyte not expressed 0.00 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0900900

Resistome Missense Mutations: K89E, E117D, H138Y

Resistome Compounds with Missense Mutations: AN13762, Desoxyepothilone B, MMV973707

Resistome # Samples with Disruptive Mutations: 4 (4 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.831 | MFS: -2.595 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3D8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109391

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 516

Non-coding: 41 | Synonymous: 133 | Nonsynonymous: 336 | Stop Codon: 6

Protein Information

Protein Length: 300 | Molecular Weight (kDa): 33.993

UniProt ID(s): Q2XR67, Q8I3D8

PDB ID(s): None

Isoelectric Point: 8.45

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006374 Variant surface antigen Stevor
PFam PF17410 Variant surface antigen Stevor
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
12477793 Small variant STEVOR antigen is uniquely located within Maurer's clefts inPlasmodium falciparum-infected red blood cells. Kaviratne M, Khan SM, Jarra W, Preiser PR 10.1128/EC.1.6.926-935.2002
15961998 Trafficking of STEVOR to the Maurer's clefts in Plasmodium falciparum-infectederythrocytes. Przyborski JM, Miller SK, ..., Lanzer M 10.1038/sj.emboj.7600720
25011110 STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediatesmerozoite invasion and rosetting. Niang M, Bei AK, ..., Preiser PR 10.1016/j.chom.2014.06.004