PF3D7_0901000 (RIF)

Genome location: Pf3D7_09_v3:58,162..59,240(-)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: rifin

SignalP Peptide: MKLQYYKILLFSISLSIFFSSSYA

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	nd	1.00
Trophozoite	possibly expressed	0.00	1.00
Schizont	possibly expressed	0.00	1.00
Gametocyte	not expressed	0.00	1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0901000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.647 | MFS: -2.387 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3D7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100719

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 537

Non-coding: 83 | Synonymous: 122 | Nonsynonymous: 332 | Stop Codon: 0

Protein Information

Protein Length: 309 | Molecular Weight (kDa): 34.805

UniProt ID(s): Q2XRC1, Q2XRF2, Q2XRF7, Q2XRH2, Q8I3D7

PDB ID(s): None

Isoelectric Point: 9.11

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006373	Variant surface antigen Rifin
PFam	PF02009	Variant surface antigen Rifin
Superfamily	N/A	N/A