About Gene List

PF3D7_0901700

Genome location: Pf3D7_09_v3:81,122..83,382(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (hyp5), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.19 0.92
Trophozoite expressed 1.44 0.35
Schizont expressed 0.40 0.77
Gametocyte not expressed 0.07 0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0901700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.953 | MFS: -3.305 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H511

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_128062

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 9 2 9
disruptive 21 16 8 33
missense 21 16 8 29

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 13 7 9
disruptive 26 40 18 33
missense 23 35 16 20

PlasmoDB Total SNPs: 78

Non-coding: 53 | Synonymous: 6 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 227 | Molecular Weight (kDa): 26.793

UniProt ID(s): C0H511

PDB ID(s): None

Isoelectric Point: 10.47

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12