Product Description: Plasmodium exported protein, unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0043657 | host cell |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.06 | 0.97 |
| Trophozoite | no data | 0.52 | 0.69 |
| Schizont | no data | 0.12 | 0.92 |
| Gametocyte | no data | 0.02 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0901800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.241 | MFS: -2.628 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H512
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 2 | 4 | 10 |
| disruptive | 10 | 20 | 18 | 26 |
| missense | 10 | 19 | 15 | 24 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 6 | 7 | 15 |
| disruptive | 17 | 50 | 19 | 49 |
| missense | 14 | 39 | 11 | 45 |
PlasmoDB Total SNPs: 90
Non-coding: 75 | Synonymous: 7 | Nonsynonymous: 8 | Stop Codon: 0
Protein Length: 269 | Molecular Weight (kDa): 32.927
UniProt ID(s): C0H512
PDB ID(s): None
Isoelectric Point: 9.9
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006410 | Conserved hypothetical protein CHP01519, Plasmodium falciparum (isolate 3D7) |
| PFam | PF09715 | Conserved hypothetical protein CHP01519, Plasmodium falciparum (isolate 3D7) |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16507167 | Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. | Sargeant TJ, Marti M, ..., Cowman AF | 10.1186/gb-2006-7-2-r12 |