About Gene List

PF3D7_0901800

Genome location: Pf3D7_09_v3:83,928..85,972(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.06 0.97
Trophozoite no data 0.52 0.69
Schizont no data 0.12 0.92
Gametocyte no data 0.02 0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0901800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.241 | MFS: -2.628 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H512

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160725

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 2 4 10
disruptive 10 20 18 26
missense 10 19 15 24

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 6 7 15
disruptive 17 50 19 49
missense 14 39 11 45

PlasmoDB Total SNPs: 90

Non-coding: 75 | Synonymous: 7 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 269 | Molecular Weight (kDa): 32.927

UniProt ID(s): C0H512

PDB ID(s): None

Isoelectric Point: 9.9

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006410 Conserved hypothetical protein CHP01519, Plasmodium falciparum (isolate 3D7)
PFam PF09715 Conserved hypothetical protein CHP01519, Plasmodium falciparum (isolate 3D7)
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12