About Gene List

PF3D7_0902200 (FIKK9.3)

Genome location: Pf3D7_09_v3:98,010..101,528(-)

Genome classification: Core

Function and Localization

Product Description: serine/threonine protein kinase, FIKK family

SignalP Peptide: MKFIGVLFLFLLNVIIYET

# Transmembrane Domains: 0

EC Numbers: 2.7.11.1 (Non-specific serine/threonine protein kinase)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0005737 cytoplasm
Component GO:0005634 nucleus
Function GO:0004674 protein serine/threonine kinase activity
Process GO:0035556 intracellular signal transduction
Process GO:0006468 protein phosphorylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.63 0.71
Trophozoite expressed 0.33 0.81
Schizont possibly expressed 0.11 0.93
Gametocyte not expressed 0.35 0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0902200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.712 | #Insertions: 6

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1225000)

  • Relative Growth Rate: 0.30 ± 0.11
  • Confidence: 5.77

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H514

"Best" AlphaFill ligand hit: IPH (phenol, Local RMSD=0.02) with 6Q7S (Global RMSD=7.84)

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
2.7.11.1 non-specific serine/threonine protein kinase ATPKClDTTP53DRBEDTATBCAKN-93K252aCKI-7LAALSTAACS...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_111291

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 24 13 22
disruptive 12 56 24 62
missense 12 55 24 54

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 43 16 31
disruptive 26 97 64 118
missense 21 85 48 87

PlasmoDB Total SNPs: 151

Non-coding: 127 | Synonymous: 18 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 633 | Molecular Weight (kDa): 74.462

UniProt ID(s): C0H514

PDB ID(s): None

Isoelectric Point: 8.28

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain superfamily
PFam PF00069 Protein kinase domain
Superfamily SSF56112 Protein kinase-like domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
17181785 A novel protein kinase family in Plasmodium falciparum is differentiallytranscribed and secreted to various cellular compartments of the host cell. Nunes MC, Goldring JP, Doerig C, Scherf A 10.1111/j.1365-2958.2006.05521.x