Genome location: Pf3D7_09_v3:113,409..115,549(-)
Genome classification: Core
Product Description: serine/threonine protein kinase, FIKK family
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 2.7.11.1 (Non-specific serine/threonine protein kinase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0004674 | protein serine/threonine kinase activity |
| Process | GO:0035556 | intracellular signal transduction |
| Process | GO:0006468 | protein phosphorylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | nd | nd |
| Trophozoite | possibly expressed | nd | nd |
| Schizont | not expressed | nd | nd |
| Gametocyte | not expressed | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0902600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.08 | #Insertions: 4
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1225000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZVB3
"Best" AlphaFill ligand hit: SGM (monothioglycerol, Local RMSD=0.18) with 3DOG (Global RMSD=9.06)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.11.1 | non-specific serine/threonine protein kinase | ATPKClDTTP53DRBEDTATBCAKN-93K252aCKI-7LAALSTAACS... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 27 | 8 | 17 |
| disruptive | 42 | 55 | 31 | 77 |
| missense | 27 | 33 | 19 | 51 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 38 | 18 | 22 |
| disruptive | 58 | 113 | 45 | 145 |
| missense | 32 | 67 | 29 | 91 |
PlasmoDB Total SNPs: 173
Non-coding: 72 | Synonymous: 51 | Nonsynonymous: 47 | Stop Codon: 3
Protein Length: 617 | Molecular Weight (kDa): 72.872
UniProt ID(s): A0A143ZVB3
PDB ID(s): None
Isoelectric Point: 6.51
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000719 | Protein kinase domain |
| InterPro | IPR008266 | Tyrosine-protein kinase, active site |
| InterPro | IPR011009 | Protein kinase-like domain superfamily |
| PFam | PF00069 | Protein kinase domain |
| Superfamily | SSF56112 | Protein kinase-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16389297 | A Plasmodium whole-genome synteny map: indels and synteny breakpoints as foci forspecies-specific genes. | Kooij TW, Carlton JM, ..., Waters AP | 10.1371/journal.ppat.0010044 |
| 15479470 | Protein kinases of the human malaria parasite Plasmodium falciparum: the kinomeof a divergent eukaryote. | Ward P, Equinet L, Packer J, Doerig C | 10.1186/1471-2164-5-79 |
| 15515182 | A genomic perspective of protein kinases in Plasmodium falciparum. | Anamika, Srinivasan N, Krupa A | 10.1002/prot.20278 |
| 17181785 | A novel protein kinase family in Plasmodium falciparum is differentiallytranscribed and secreted to various cellular compartments of the host cell. | Nunes MC, Goldring JP, Doerig C, Scherf A | 10.1111/j.1365-2958.2006.05521.x |