Product Description: serine repeat antigen 9
SignalP Peptide: MKVSFTLFFIIYIILNCDVLKC
# Transmembrane Domains: 0
EC Numbers: 3.4.22.2 (Papain)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005615 | extracellular space |
| Component | GO:0005764 | lysosome |
| Function | GO:0004197 | cysteine-type endopeptidase activity |
| Process | GO:0002377 | immunoglobulin production |
| Process | GO:0051603 | proteolysis involved in cellular protein catabolic process |
| Process | GO:0050776 | regulation of immune response |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.14 | 0.94 |
| Trophozoite | expressed | 1.31 | 0.43 |
| Schizont | expressed | 0.43 | 0.79 |
| Gametocyte | not expressed | 0.16 | 0.92 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0902800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.045 | #Insertions: 7
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0305100)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0305100)
Modification: Disrupted | RMgm-1762
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3C0
"Best" AlphaFill ligand hit: PGO (s-1,2-propanediol, Local RMSD=0.03) with 4X6J (Global RMSD=2.96)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.4.22.2 | papain | DFPE64HgCl2CpPRIethanolmethanolantipainchitosanchagasincystatinPdKl-3.1PdKl-3.2... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 31 | 27 | 44 |
| disruptive | 18 | 136 | 65 | 157 |
| missense | 18 | 134 | 64 | 148 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 64 | 32 | 49 |
| disruptive | 43 | 248 | 105 | 233 |
| missense | 42 | 237 | 98 | 179 |
PlasmoDB Total SNPs: 141
Non-coding: 88 | Synonymous: 26 | Nonsynonymous: 27 | Stop Codon: 0
Protein Length: 932 | Molecular Weight (kDa): 105.544
UniProt ID(s): A0A0E3VL35, A0A0E4B249, A0A0E4FHW8, Q8I3C0
PDB ID(s): None
Isoelectric Point: 4.91
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000668 | Peptidase C1A, papain C-terminal |
| InterPro | IPR025660 | Cysteine peptidase, histidine active site |
| InterPro | IPR038765 | Papain-like cysteine peptidase superfamily |
| PFam | PF00112 | Peptidase C1A, papain C-terminal |
| Superfamily | SSF54001 | Papain-like cysteine peptidase superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12228245 | A subset of Plasmodium falciparum SERA genes are expressed and appear to play animportant role in the erythrocytic cycle. | Miller SK, Good RT, ..., Crabb BS | 10.1074/jbc.M206974200 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 17893128 | Evidence for a common role for the serine-type Plasmodium falciparum serinerepeat antigen proteases: implications for vaccine and drug design | McCoubrie JE, Miller SK, ..., Crabb BS | 10.1128/IAI.00405-07 |