PF3D7_0902900

Genome location: Pf3D7_09_v3:127,416..127,724(+)

Genome classification: Core

Function and Localization

Product Description: early transcribed membrane protein, putative

SignalP Peptide: MKNSQNFTFIIILLISLIFISSC

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.00	1.00
Schizont	no data	0.00	1.00
Gametocyte	no data	0.00	1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0902900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.12 | MFS: -3.751 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3B9

"Best" AlphaFill ligand hit: CLA (chlorophyll a, Local RMSD=0.01) with 6FOS (Global RMSD=12.68)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533117

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	3	6	7
disruptive	15	11	3	13
missense	15	9	2	6

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	9	5	10
disruptive	20	21	9	26
missense	19	12	5	19

PlasmoDB Total SNPs: 16

Non-coding: 0 | Synonymous: 4 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 102 | Molecular Weight (kDa): 11.776

UniProt ID(s): Q8I3B9

PDB ID(s): None

Isoelectric Point: 9.8

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006389	Early transcribed membrane protein (ETRAMP)
PFam	PF09716	Early transcribed membrane protein (ETRAMP)
Superfamily	N/A	N/A