About Gene List

PF3D7_0903000

Genome location: Pf3D7_09_v3:128,833..130,079(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.06 0.97
Trophozoite expressed 0.47 0.72
Schizont expressed 0.17 0.89
Gametocyte expressed 0.50 0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0903000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.696 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3B8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139423

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 8 3 8
disruptive 1 15 19 24
missense 1 15 18 22

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 17 4 14
disruptive 5 51 25 51
missense 3 42 22 35

PlasmoDB Total SNPs: 49

Non-coding: 39 | Synonymous: 6 | Nonsynonymous: 3 | Stop Codon: 1

Protein Information

Protein Length: 158 | Molecular Weight (kDa): 18.831

UniProt ID(s): Q8I3B8

PDB ID(s): None

Isoelectric Point: 10.07

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21