PF3D7_0903100 (RER1)

Genome location: Pf3D7_09_v3:130,060..131,208(-)

Genome classification: Core

Function and Localization

Product Description: protein RER1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
Component	GO:0030173	integral component of Golgi membrane
Process	GO:0006621	protein retention in ER lumen
Process	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.07	0.97
Trophozoite	expressed	0.09	0.94
Schizont	expressed	0.04	0.97
Gametocyte	expressed	0.11	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0903100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.143 | MFS: -3.083 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0418300)

Relative Growth Rate: 0.76 ± 0.06
Confidence: 6.91

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0418300)

Modification: Disrupted | RMgm-1931

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3B7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101272

Most Similar Human Ortholog: A0A0A0MR06

TM-align score: 0.84 | RMSD: 2.76

Seq Identity: 0.41 | Length: 167 / 201

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000157916	retention in endoplasmic reticulum sorting receptor 1
ENSG00000173662	taste 1 receptor member 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	14	10	10
disruptive	2	15	11	23
missense	2	15	11	20

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	31	3	8
disruptive	5	46	23	62
missense	5	37	20	34

PlasmoDB Total SNPs: 39

Non-coding: 29 | Synonymous: 6 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 201 | Molecular Weight (kDa): 24.197

UniProt ID(s): Q8I3B7

PDB ID(s): None

Isoelectric Point: 9.48

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004932	Retrieval of early ER protein Rer1
PFam	PF03248	Retrieval of early ER protein Rer1
Superfamily	N/A	N/A