Product Description: ras-related protein RAB7
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.6.5.2 (Small monomeric GTPase)
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005768 | endosome |
Component | GO:0016020 | membrane |
Component | GO:0005773 | vacuole |
Function | GO:0003924 | GTPase activity |
Function | GO:0005515 | protein binding |
Function | GO:1905394 | retromer complex binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | no data | N/A | N/A |
Ring | no data | 0.14 | 0.93 |
Trophozoite | no data | 0.87 | 0.53 |
Schizont | no data | 0.34 | 0.79 |
Gametocyte | no data | 0.26 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0903200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.151 | MFS: -3.106 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0521700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H516
"Best" AlphaFill ligand hit: BEZ (benzoic acid, Local RMSD=0.03) with 1S8F (Global RMSD=1.44)
BRENDA EC Inhibitors:
EC # | Name | EC Inhibitors |
---|---|---|
3.6.5.2 | small monomeric GTPase | GTPGDPEDTAPlexAstatinCCG-977Rap1GapNSC23766CCG-1423Rap1GAP1GTPgammaSCalmodulin... |
Orthology to BindingDB Entries:
Ortholog Group (OrthoMCL): OG6_101358
Most Similar Human Ortholog: C9J592
TM-align score: 0.99 | RMSD: 0.54
Seq Identity: 0.74 | Length: 150 / 206
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000075785 | RAB7A, member RAS oncogene family |
Protein Length: 206 | Molecular Weight (kDa): 23.788
PDB ID(s): None
Isoelectric Point: 7.56
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR001806 | Small GTPase |
InterPro | IPR005225 | Small GTP-binding protein domain |
InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
PFam | PF00071 | Small GTPase |
Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 0 | 0 | 0 | 0 |
disruptive | 0 | 0 | 0 | 0 |
missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 0 | 0 | 0 | 0 |
disruptive | 0 | 0 | 1 | 0 |
missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 182
Non-coding: 178 | Synonymous: 3 | Nonsynonymous: 1 | Stop Codon: 0
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
22188458 | Construction of a Plasmodium falciparum Rab-interactome identifies CK1 and PKA asRab-effector kinases in malaria parasites. | Rached FB, Ndjembo-Ezougou C, ..., Langsley G | 10.1111/boc.201100081 |
24587025 | Evidence for a Golgi-to-endosome protein sorting pathway in Plasmodiumfalciparum. | Krai P, Dalal S, Klemba M | 10.1371/journal.pone.0089771 |
32512169 | Rab7 of Plasmodium falciparum is involved in its retromer complex assembly nearthe digestive vacuole. | Siddiqui AA, Saha D, ..., Bandyopadhyay U | 10.1016/j.bbagen.2020.129656 |