About Gene List

PF3D7_0903200 (RAB7)

Genome location: Pf3D7_09_v3:133,034..136,372(-)

Genome classification: Core

Function and Localization

Product Description: ras-related protein RAB7

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.6.5.2 (Small monomeric GTPase)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005768 endosome
Component GO:0016020 membrane
Component GO:0005773 vacuole
Function GO:0003924 GTPase activity
Function GO:0005515 protein binding
Function GO:1905394 retromer complex binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.14 0.93
Trophozoite no data 0.87 0.53
Schizont no data 0.34 0.79
Gametocyte no data 0.26 0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0903200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.151 | MFS: -3.106 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0521700)

  • Relative Growth Rate: 0.04 ± 0.08
  • Confidence: 6.45

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H516

"Best" AlphaFill ligand hit: BEZ (benzoic acid, Local RMSD=0.03) with 1S8F (Global RMSD=1.44)

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
3.6.5.2 small monomeric GTPase GTPGDPEDTAPlexAstatinCCG-977Rap1GapNSC23766CCG-1423Rap1GAP1GTPgammaSCalmodulin...

Orthology to BindingDB Entries:

UniProt Protein Name Species Homology Source BindingDB Ligands
P18067 Ras-related protein Rab-7a Canis lupus dingo HOGENOM, OrthoDB, OrthoMCL, OrthoMCL BLAST UNM-0000306062UNM-0000306065UNM-0000306068UNM-0000306070...
O14966 Ras-related protein Rab-7L1 HOGENOM CHEMBL3893914

Orthology Information

Ortholog Group (OrthoMCL): OG6_101358

Most Similar Human Ortholog: C9J592

TM-align score: 0.99 | RMSD: 0.54

Seq Identity: 0.74 | Length: 150 / 206

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000075785 RAB7A, member RAS oncogene family

Protein Information

Protein Length: 206 | Molecular Weight (kDa): 23.788

UniProt ID(s): C0H516, Q9NFG0

PDB ID(s): None

Isoelectric Point: 7.56

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001806 Small GTPase
InterPro IPR005225 Small GTP-binding protein domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFam PF00071 Small GTPase
Superfamily SSF52540 P-loop containing nucleoside triphosphate hydrolase

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 0 0 0
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 0 1 0
missense 0 0 0 0

PlasmoDB Total SNPs: 182

Non-coding: 178 | Synonymous: 3 | Nonsynonymous: 1 | Stop Codon: 0

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
22188458 Construction of a Plasmodium falciparum Rab-interactome identifies CK1 and PKA asRab-effector kinases in malaria parasites. Rached FB, Ndjembo-Ezougou C, ..., Langsley G 10.1111/boc.201100081
24587025 Evidence for a Golgi-to-endosome protein sorting pathway in Plasmodiumfalciparum. Krai P, Dalal S, Klemba M 10.1371/journal.pone.0089771
32512169 Rab7 of Plasmodium falciparum is involved in its retromer complex assembly nearthe digestive vacuole. Siddiqui AA, Saha D, ..., Bandyopadhyay U 10.1016/j.bbagen.2020.129656