About Gene List

PF3D7_0903300

Genome location: Pf3D7_09_v3:138,715..151,403(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 6

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.13 0.94
Trophozoite expressed 1.16 0.52
Schizont expressed 1.40 0.49
Gametocyte possibly expressed 1.17 0.46

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0903300

Resistome Missense Mutations: I201K

Resistome Compounds with Missense Mutations: TCMDC-124553/MMV019869

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.656 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0418100)

Modification: Disrupted | RMgm-1929

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532548

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 48 245 127 220
disruptive 163 755 354 720
missense 143 687 321 628

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 96 426 157 255
disruptive 361 1444 517 1051
missense 280 1236 429 619

PlasmoDB Total SNPs: 625

Non-coding: 221 | Synonymous: 216 | Nonsynonymous: 186 | Stop Codon: 2

Protein Information

Protein Length: 3203 | Molecular Weight (kDa): 380.982

UniProt ID(s): C0H517

PDB ID(s): None

Isoelectric Point: 9.59

Protein Domain Annotations:

Source Family ID Description
InterPro IPR011009 Protein kinase-like domain superfamily
PFam N/A N/A
Superfamily SSF56112 Protein kinase-like domain superfamily

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104