About Gene List

PF3D7_0903500 (NUP138)

Genome location: Pf3D7_09_v3:162,043..167,477(+)

Genome classification: Core

Function and Localization

Product Description: nucleoporin NUP138, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005643 nuclear pore
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.85 0.61
Trophozoite expressed 0.59 0.66
Schizont not expressed 0.22 0.86
Gametocyte not expressed 0.44 0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0903500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.979 | MFS: -2.833 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0417900)

Modification: Tagged | RMgm-5239

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3B3

"Best" AlphaFill ligand hit: DHS (3-amino-4,5-dihydroxy-cyclohex-1-enecarboxylate, Local RMSD=0.68) with 3JS3 (Global RMSD=45.66)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532870

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 34 89 49 95
disruptive 72 261 147 288
missense 33 211 129 254

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 43 171 56 108
disruptive 123 530 186 378
missense 58 430 162 281

PlasmoDB Total SNPs: 228

Non-coding: 87 | Synonymous: 90 | Nonsynonymous: 51 | Stop Codon: 0

Protein Information

Protein Length: 1384 | Molecular Weight (kDa): 155.152

UniProt ID(s): Q8I3B3

PDB ID(s): None

Isoelectric Point: 5.69

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
30050042 Nuclear Pore Complex Components in the Malaria Parasite Plasmodium berghei. Kehrer J, Kuss C, ..., Frischknecht F 10.1038/s41598-018-29590-5
38405843 Nuclear pore complexes undergo Nup221 exchange during blood stage asexualreplication of Plasmodium parasites Blauwkamp JA, Ambekar SV, ..., Absalon S 10.1101/2024.02.16.580747