Product Description: nucleoporin NUP138, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005643 | nuclear pore |
Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | expressed | 0.85 | 0.61 |
Trophozoite | expressed | 0.59 | 0.66 |
Schizont | not expressed | 0.22 | 0.86 |
Gametocyte | not expressed | 0.44 | 0.75 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0903500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.979 | MFS: -2.833 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0417900)
Modification: Tagged | RMgm-5239
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3B3
"Best" AlphaFill ligand hit: DHS (3-amino-4,5-dihydroxy-cyclohex-1-enecarboxylate, Local RMSD=0.68) with 3JS3 (Global RMSD=45.66)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 34 | 89 | 49 | 95 |
disruptive | 72 | 261 | 147 | 288 |
missense | 33 | 211 | 129 | 254 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 43 | 171 | 56 | 108 |
disruptive | 123 | 530 | 186 | 378 |
missense | 58 | 430 | 162 | 281 |
PlasmoDB Total SNPs: 228
Non-coding: 87 | Synonymous: 90 | Nonsynonymous: 51 | Stop Codon: 0
Protein Length: 1384 | Molecular Weight (kDa): 155.152
UniProt ID(s): Q8I3B3
PDB ID(s): None
Isoelectric Point: 5.69
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | N/A | N/A |
PFam | N/A | N/A |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
30050042 | Nuclear Pore Complex Components in the Malaria Parasite Plasmodium berghei. | Kehrer J, Kuss C, ..., Frischknecht F | 10.1038/s41598-018-29590-5 |
38405843 | Nuclear pore complexes undergo Nup221 exchange during blood stage asexualreplication of Plasmodium parasites | Blauwkamp JA, Ambekar SV, ..., Absalon S | 10.1101/2024.02.16.580747 |