About Gene List

PF3D7_0903600

Genome location: Pf3D7_09_v3:168,458..173,493(+)

Genome classification: Core

Function and Localization

Product Description: protein hook, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020009 microneme

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed nd nd
Trophozoite not expressed nd nd
Schizont expressed nd nd
Gametocyte possibly expressed nd nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0903600.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.22 | MFS: -2.66 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0417800)

  • Relative Growth Rate: 1.00 ± 0.06
  • Confidence: 6.96

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0417800)

Modification: Disrupted | RMgm-1926

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZVB6

"Best" AlphaFill ligand hit: DXC ((3alpha,5beta,12alpha)-3,12-dihydroxycholan-24-oic acid, Local RMSD=0.16) with 3R9V (Global RMSD=4.94)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_151783

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 55 28 43
disruptive 20 78 37 108
missense 18 72 34 96

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 15 94 25 60
disruptive 35 195 91 175
missense 25 154 76 128

PlasmoDB Total SNPs: 255

Non-coding: 208 | Synonymous: 27 | Nonsynonymous: 20 | Stop Codon: 0

Protein Information

Protein Length: 760 | Molecular Weight (kDa): 90.677

UniProt ID(s): A0A143ZVB6

PDB ID(s): None

Isoelectric Point: 5.06

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily SSF116907 N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104