Product Description: LCCL domain-containing protein
SignalP Peptide: MYNFFLSIICIFFIPYFCRA
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0044312 | crystalloid |
| Component | GO:0020003 | symbiont-containing vacuole |
| Function | GO:0005515 | protein binding |
| Function | GO:0044877 | protein-containing complex binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.02 | 0.99 |
| Trophozoite | not expressed | 0.02 | 0.99 |
| Schizont | not expressed | 0.02 | 0.99 |
| Gametocyte | expressed | 0.73 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0903800
Resistome Missense Mutations: R988I
Resistome Compounds with Missense Mutations: Suloctidil
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.241 | #Insertions: 11
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0417600)
Modification: Tagged | RMgm-878
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3B1
"Best" AlphaFill ligand hit: MPO (3[n-morpholino]propane sulfonic acid, Local RMSD=3.20) with 4LXX (Global RMSD=21.77)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 29 | 106 | 54 | 121 |
| disruptive | 55 | 193 | 111 | 263 |
| missense | 31 | 147 | 92 | 202 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 52 | 175 | 88 | 117 |
| disruptive | 111 | 395 | 182 | 363 |
| missense | 55 | 296 | 141 | 247 |
PlasmoDB Total SNPs: 160
Non-coding: 17 | Synonymous: 83 | Nonsynonymous: 59 | Stop Codon: 1
Protein Length: 1523 | Molecular Weight (kDa): 178.335
UniProt ID(s): Q8I3B1
PDB ID(s): None
Isoelectric Point: 8.9
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004043 | LCCL domain |
| InterPro | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| InterPro | IPR029365 | TMEM238 protein |
| InterPro | IPR036609 | LCCL domain superfamily |
| PFam | PF03815 | LCCL domain |
| Superfamily | SSF49899 | Concanavalin A-like lectin/glucanase domain superfamily |
| Superfamily | SSF56988 | LCCL domain superfamily |
| Superfamily | SSF69848 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 17950739 | PfCCp proteins of Plasmodium falciparum: gametocyte-specific expression and rolein complement-mediated inhibition of exflagellation. | Scholz SM, Simon N, ..., Pradel G | 10.1016/j.ijpara.2007.08.009 |
| 23684590 | Translational repression controls temporal expression of the Plasmodium bergheiLCCL protein complex. | Saeed S, Carter V, Tremp AZ, Dessens JT | 10.1016/j.molbiopara.2013.04.006 |
| 26408859 | Adhesion protein complexes of malaria gametocytes assemble following parasitetransmission to the mosquito. | Simon N, Kuehn A, Williamson KC, Pradel G | 10.1016/j.parint.2015.09.007 |