Product Description: 60S ribosomal protein L32
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 1.71 | 0.32 |
| Trophozoite | expressed | 1.80 | 0.24 |
| Schizont | expressed | 0.41 | 0.75 |
| Gametocyte | expressed | 0.99 | 0.50 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0903900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.861 | MFS: -2.274 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0417500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3B0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100702
Most Similar Human Ortholog: F8W727
TM-align score: 0.96 | RMSD: 1.03
Seq Identity: 0.58 | Length: 129 / 131
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000144713 | ribosomal protein L32 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 6 | 0 | 6 |
| disruptive | 0 | 2 | 1 | 12 |
| missense | 0 | 2 | 1 | 11 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 8 | 7 | 4 |
| disruptive | 3 | 17 | 12 | 45 |
| missense | 0 | 11 | 11 | 27 |
PlasmoDB Total SNPs: 96
Non-coding: 87 | Synonymous: 6 | Nonsynonymous: 1 | Stop Codon: 2
Protein Length: 131 | Molecular Weight (kDa): 15.527
UniProt ID(s): Q8I3B0
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 11.7
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001515 | Ribosomal protein L32e |
| InterPro | IPR018263 | Ribosomal protein L32e, conserved site |
| InterPro | IPR036351 | Ribosomal protein L32e superfamily |
| PFam | PF01655 | Ribosomal protein L32e |
| Superfamily | SSF52042 | Ribosomal protein L32e superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |