About Gene List

PF3D7_0904000

Genome location: Pf3D7_09_v3:186,468..190,718(-)

Genome classification: Core

Function and Localization

Product Description: GTPase-activating protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 1.25 0.46
Trophozoite expressed 1.18 0.42
Schizont expressed 0.42 0.75
Gametocyte expressed 1.85 0.27

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0904000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.074 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0417400)

  • Relative Growth Rate: 0.39 ± 0.22
  • Confidence: 4.46

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0417400)

Modification: Disrupted | RMgm-1923

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3A9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_114984

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 249

Non-coding: 235 | Synonymous: 9 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 426 | Molecular Weight (kDa): 50.301

UniProt ID(s): Q8I3A9

PDB ID(s): None

Isoelectric Point: 4.55

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000195 Rab-GTPase-TBC domain
InterPro IPR035969 Rab-GTPase-TBC domain superfamily
PFam PF00566 Rab-GTPase-TBC domain
Superfamily SSF47923 Rab-GTPase-TBC domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108