Product Description: AP-4 complex subunit epsilon, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030124 | AP-4 adaptor complex |
| Function | GO:0140312 | cargo adaptor activity |
| Process | GO:0006898 | receptor-mediated endocytosis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.16 | 0.92 |
| Trophozoite | not expressed | 0.57 | 0.67 |
| Schizont | not expressed | 0.26 | 0.83 |
| Gametocyte | not expressed | 0.45 | 0.73 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0904100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.149 | MFS: -2.777 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0417300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3A8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104838
Most Similar Human Ortholog: H0YK94
TM-align score: 0.91 | RMSD: 1.96
Seq Identity: 0.45 | Length: 218 / 1388
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000081014 | adaptor related protein complex 4 subunit epsilon 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 81 | 44 | 100 |
| disruptive | 57 | 237 | 107 | 310 |
| missense | 33 | 198 | 84 | 241 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 34 | 165 | 56 | 100 |
| disruptive | 124 | 486 | 220 | 391 |
| missense | 71 | 378 | 161 | 274 |
PlasmoDB Total SNPs: 219
Non-coding: 69 | Synonymous: 96 | Nonsynonymous: 54 | Stop Codon: 0
Protein Length: 1388 | Molecular Weight (kDa): 161.406
UniProt ID(s): Q8I3A8
PDB ID(s): None
Isoelectric Point: 5.38
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002553 | Clathrin/coatomer adaptor, adaptin-like, N-terminal |
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR017109 | Adaptor protein complex AP-4, epsilon subunit |
| PFam | PF01602 | Clathrin/coatomer adaptor, adaptin-like, N-terminal |
| Superfamily | SSF48371 | Armadillo-type fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |