About Gene List

PF3D7_0904200 (PH)

Genome location: Pf3D7_09_v3:197,658..198,894(+)

Genome classification: Core

Function and Localization

Product Description: PH domain-containing protein, putative

SignalP Peptide: MNYLKLFLFLFLVNILNIYG

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface
Component GO:0044312 crystalloid

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite not expressed 0.04 0.98
Schizont not expressed 0.02 0.99
Gametocyte expressed 1.65 0.56

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0904200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.22 | MFS: -2.9 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0417200)

Modification: Tagged | RMgm-4862

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3A7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130916

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 16 9 32
disruptive 21 59 27 61
missense 8 48 20 53

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 38 25 28
disruptive 36 106 32 78
missense 15 82 27 53

PlasmoDB Total SNPs: 73

Non-coding: 40 | Synonymous: 17 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 292 | Molecular Weight (kDa): 33.993

UniProt ID(s): Q8I3A7

PDB ID(s): None

Isoelectric Point: 5.03

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
27038925 Characterization of a Plasmodium berghei sexual stage antigen PbPH as a newcandidate for malaria transmission-blocking vaccine. Kou X, Zheng W, ..., Cao Y 10.1186/s13071-016-1459-8
32736136 Plasmodium berghei LAPs form an extended protein complex that facilitatescrystalloid targeting and biogenesis. Tremp AZ, Saeed S, ..., Dessens JT 10.1016/j.jprot.2020.103925