PF3D7_0904300

Genome location: Pf3D7_09_v3:199,051..207,458(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MSCINKLPLFIILIIYETLNKNWG

# Transmembrane Domains: 11

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0009986	cell surface
Component	GO:0005615	extracellular space
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	not expressed	0.11	0.94
Schizont	not expressed	0.11	0.93
Gametocyte	expressed	0.51	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0904300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.416 | #Insertions: 9

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0417100)

Relative Growth Rate: 0.96 ± 0.20
Confidence: 4.64

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PbANKA_0417100)

Modification: Disrupted | RMgm-4327

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H518

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=0.59) with 3AM1 (Global RMSD=14.23)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_170774

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	31	109	79	170
disruptive	85	383	211	508
missense	66	350	202	470

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	47	236	126	174
disruptive	164	773	353	575
missense	116	683	317	456

PlasmoDB Total SNPs: 285

Non-coding: 115 | Synonymous: 82 | Nonsynonymous: 88 | Stop Codon: 0

Protein Information

Protein Length: 2487 | Molecular Weight (kDa): 296.791

UniProt ID(s): C0H518

PDB ID(s): None

Isoelectric Point: 9.05

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011641	Tyrosine-protein kinase ephrin type A/B receptor-like
PFam	PF07699	Tyrosine-protein kinase ephrin type A/B receptor-like
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
11152613	Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes.	Krogh A, Larsson B, von Heijne G, Sonnhammer EL	10.1006/jmbi.2000.4315
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095