Product Description: signal peptidase complex subunit 3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 3.4.21.89 (Signal peptidase I)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0044310 | osmiophilic body |
| Component | GO:0005787 | signal peptidase complex |
| Process | GO:0045047 | protein targeting to ER |
| Process | GO:0006465 | signal peptide processing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.03 | 0.98 |
| Trophozoite | expressed | 0.33 | 0.79 |
| Schizont | expressed | 0.17 | 0.88 |
| Gametocyte | expressed | 0.12 | 0.92 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0904400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.071 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3A5
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.4.21.89 | Signal peptidase I | NEMSDSEDTAMG132cholateantipainL685,458rifampicinBAL0019193arylomycinlactacystindeoxycholate... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102447
Most Similar Human Ortholog: P61009
TM-align score: 0.85 | RMSD: 2.14
Seq Identity: 0.27 | Length: 172 / 185
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000129128 | signal peptidase complex subunit 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 9 | 4 | 17 |
| disruptive | 1 | 12 | 5 | 10 |
| missense | 1 | 11 | 4 | 10 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 24 | 7 | 12 |
| disruptive | 6 | 29 | 18 | 51 |
| missense | 5 | 20 | 15 | 18 |
PlasmoDB Total SNPs: 107
Non-coding: 99 | Synonymous: 6 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 185 | Molecular Weight (kDa): 22.209
UniProt ID(s): Q8I3A5
PDB ID(s): None
Isoelectric Point: 9.62
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007653 | Signal peptidase complex subunit 3 |
| PFam | PF04573 | Signal peptidase complex subunit 3 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16873890 | Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 andmalaria signal peptide peptidase. | Nyborg AC, Ladd TB, ..., Golde TE | 10.1096/fj.06-5762com |
| 18160114 | A Presenilin-like protease associated with Plasmodium falciparum micronemes isinvolved in erythrocyte invasion. | Li X, Chen H, Oh SS, Chishti AH | 10.1016/j.molbiopara.2007.11.007 |
| 19174148 | Plasmodium falciparum signal peptide peptidase is a promising drug target againstblood stage malaria. | Li X, Chen H, ..., Chishti AH | https://pubmed.ncbi.nlm.nih.gov/19174148/ |
| 27432909 | Comparative Proteomics and Functional Analysis Reveal a Role of Plasmodiumfalciparum Osmiophilic Bodies in Malaria Parasite Transmission. | Suarez-Cortes P, Sharma V, ..., Alano P | 10.1074/mcp.M116.060681 |