PF3D7_0904500

Genome location: Pf3D7_09_v3:209,347..211,040(+)

Genome classification: Core

Function and Localization

Product Description: prefoldin subunit 4, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0016272	prefoldin complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	not expressed	0.34	0.78
Schizont	not expressed	0.07	0.95
Gametocyte	not expressed	0.32	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0904500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.153 | MFS: -2.753 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0416900)

Relative Growth Rate: 0.87 ± 0.08
Confidence: 6.37

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0416900)

Modification: Disrupted | RMgm-1920

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3A4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102908

Most Similar Human Ortholog: E9PQY2

TM-align score: 0.84 | RMSD: 1.56

Seq Identity: 0.28 | Length: 118 / 129

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000101132	prefoldin subunit 4

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 129

Non-coding: 120 | Synonymous: 8 | Nonsynonymous: 0 | Stop Codon: 1

Protein Information

Protein Length: 129 | Molecular Weight (kDa): 15.325

UniProt ID(s): Q8I3A4

PDB ID(s): None

Isoelectric Point: 4.58

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002777	Prefoldin beta-like
InterPro	IPR016661	Prefoldin, subunit 4
PFam	PF01920	Prefoldin beta-like
Superfamily	SSF46579	N/A