Product Description: ubiquitin specific protease, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.4.19.12 (Ubiquitinyl hydrolase 1)
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.49 | 0.76 |
| Trophozoite | expressed | 0.77 | 0.58 |
| Schizont | expressed | 0.79 | 0.55 |
| Gametocyte | possibly expressed | 0.89 | 0.54 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0904600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.998 | MFS: -2.476 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0416800)
Modification: Disrupted | RMgm-1919
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3A3
"Best" AlphaFill ligand hit: MIX (mitoxantrone, Local RMSD=0.05) with 7R2G (Global RMSD=5.54)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.4.19.12 | ubiquitinyl hydrolase 1 | KClNEMDTTEDTAEGTARNAisiRNApeptidesAntibodyubiquitinLDN-574442-propenal... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Homo sapiens | OrthoDB | LCACNLCAELCAHALCAE... |
| P40818 | Ubiquitin carboxyl-terminal hydrolase 8 | Homo sapiens | OrthoDB | CHEMBL2398212CHEMBL5172138CHEMBL5196686CHEMBL5173239... |
| Q9P275 | Ubiquitin carboxyl-terminal hydrolase 36 | OrthoDB | CHEMBL5172138CHEMBL5173239CHEMBL5185273 | |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | OrthoDB | 9-(4-(3,5-dimethyl-1H-US10189841, Compound I-2US10399980, Compound I-3US10399980, Compound I-4... | |
| Q70CQ3 | Ubiquitin carboxyl-terminal hydrolase 30 | OrthoDB | US11066365, Example 1US11390584, Example 2US11390584, Example 3US11390584, Example 4... |
Ortholog Group (OrthoMCL): OG6_101457
Most Similar Human Ortholog: K7EMM6
TM-align score: 0.68 | RMSD: 2.94
Seq Identity: 0.27 | Length: 200 / 1770
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000055483 | ubiquitin specific peptidase 36 |
| ENSG00000106346 | ubiquitin specific peptidase 42 |
Protein Length: 1770 | Molecular Weight (kDa): 207.568
UniProt ID(s): Q8I3A3
PDB ID(s): None
Isoelectric Point: 6.05
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001394 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
| InterPro | IPR006615 | Peptidase C19, ubiquitin-specific peptidase, DUSP domain |
| InterPro | IPR018200 | Ubiquitin specific protease, conserved site |
| InterPro | IPR035927 | DUSP-like superfamily |
| InterPro | IPR038765 | Papain-like cysteine peptidase superfamily |
| PFam | PF00443 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
| PFam | PF06337 | Peptidase C19, ubiquitin-specific peptidase, DUSP domain |
| Superfamily | SSF143791 | DUSP-like superfamily |
| Superfamily | SSF54001 | Papain-like cysteine peptidase superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 24 | 120 | 67 | 124 |
| disruptive | 75 | 309 | 205 | 384 |
| missense | 48 | 245 | 163 | 318 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 48 | 246 | 90 | 118 |
| disruptive | 160 | 752 | 288 | 669 |
| missense | 97 | 561 | 217 | 369 |
PlasmoDB Total SNPs: 425
Non-coding: 169 | Synonymous: 124 | Nonsynonymous: 132 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |