About Gene List

PF3D7_0904700 (HU)

Genome location: Pf3D7_09_v3:218,206..219,855(-)

Genome classification: Core

Function and Localization

Product Description: bacterial histone-like protein

SignalP Peptide: MYVILYCVLFLFQVVYS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast
Component GO:0005634 nucleus
Function GO:0003677 DNA binding
Process GO:0051262 protein tetramerization

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.03 0.98
Trophozoite expressed 0.47 0.72
Schizont expressed 0.29 0.82
Gametocyte expressed 0.32 0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0904700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.083 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3A2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103534

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 14 4 17
disruptive 2 6 13 20
missense 2 6 12 20

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 22 12 23
disruptive 2 41 22 44
missense 2 31 17 29

PlasmoDB Total SNPs: 67

Non-coding: 51 | Synonymous: 15 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 189 | Molecular Weight (kDa): 22.515

UniProt ID(s): C1KUR4, Q8I3A2

PDB ID(s): None

Isoelectric Point: 9.86

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000119 Histone-like DNA-binding protein
InterPro IPR010992 Integration host factor (IHF)-like DNA-binding domain superfamily
PFam PF00216 Histone-like DNA-binding protein
Superfamily SSF47729 Integration host factor (IHF)-like DNA-binding domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
18663012 DNA organization by the apicoplast-targeted bacterial histone-like protein ofPlasmodium falciparum. Ram EV, Naik R, Ganguli M, Habib S 10.1093/nar/gkn483
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596