PF3D7_0905000 (ATPTG4)

Genome location: Pf3D7_09_v3:234,018..235,610(-)

Genome classification: Core

Function and Localization

Product Description: ATP synthase-associated protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.23	0.85
Schizont	not expressed	0.06	0.95
Gametocyte	not expressed	0.29	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0905000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.15 | MFS: -3.29 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0416400)

Relative Growth Rate: 0.84 ± 0.12
Confidence: 5.62

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0416400)

Modification: Disrupted | RMgm-1918

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I399

"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=1.96) with 3QV2 (Global RMSD=24.68)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139438

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	13	5	17
disruptive	3	29	27	43
missense	3	28	26	42

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	25	14	18
disruptive	9	79	42	76
missense	6	70	33	58

PlasmoDB Total SNPs: 94

Non-coding: 69 | Synonymous: 17 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 281 | Molecular Weight (kDa): 34.031

UniProt ID(s): Q8I399

PDB ID(s): None

Isoelectric Point: 9.16

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR036249	Thioredoxin-like superfamily
PFam	N/A	N/A
Superfamily	SSF52833	Thioredoxin-like superfamily

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108