Product Description: mitochondrial carrier protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0005381 | iron ion transmembrane transporter activity |
| Process | GO:0048250 | iron import into the mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.42 | 0.79 |
| Trophozoite | possibly expressed | 0.24 | 0.86 |
| Schizont | possibly expressed | 0.08 | 0.95 |
| Gametocyte | not expressed | 0.17 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0905200
Resistome Missense Mutations: K190N
Resistome Compounds with Missense Mutations: Atovaquone
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.135 | MFS: -2.88 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0416200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I397
"Best" AlphaFill ligand hit: HEM (heme, Local RMSD=0.80) with 8A8L (Global RMSD=27.15)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101882
Most Similar Human Ortholog: Q9NYZ2
TM-align score: 0.65 | RMSD: 4.69
Seq Identity: 0.27 | Length: 296 / 1199
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000147454 | solute carrier family 25 member 37 |
| ENSG00000155287 | solute carrier family 25 member 28 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 65 | 41 | 70 |
| disruptive | 50 | 208 | 149 | 259 |
| missense | 35 | 201 | 141 | 230 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 28 | 114 | 49 | 81 |
| disruptive | 86 | 435 | 162 | 307 |
| missense | 66 | 391 | 143 | 255 |
PlasmoDB Total SNPs: 136
Non-coding: 38 | Synonymous: 44 | Nonsynonymous: 54 | Stop Codon: 0
Protein Length: 1199 | Molecular Weight (kDa): 142.072
UniProt ID(s): Q8I397
PDB ID(s): None
Isoelectric Point: 10.05
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR018108 | Mitochondrial substrate/solute carrier |
| InterPro | IPR023395 | Mitochondrial carrier domain superfamily |
| PFam | PF00153 | Mitochondrial substrate/solute carrier |
| Superfamily | SSF103506 | Mitochondrial carrier domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |