PF3D7_0905300

Genome location: Pf3D7_09_v3:251,353..269,709(-)

Genome classification: Core

Function and Localization

Product Description: dynein heavy chain, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030286	dynein complex
Component	GO:0036157	outer dynein arm
Function	GO:0045505	dynein intermediate chain binding
Function	GO:0051959	dynein light intermediate chain binding
Function	GO:0008569	minus-end-directed microtubule motor activity
Process	GO:0007018	microtubule-based movement
Process	GO:0036158	outer dynein arm assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	not expressed	0.11	0.94
Schizont	not expressed	0.51	0.74
Gametocyte	not expressed	1.11	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0905300

Resistome Missense Mutations: V4001E

Resistome Compounds with Missense Mutations: AN10248

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 2 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.196 | #Insertions: 25

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0925400)

Relative Growth Rate: 0.16 ± 0.46
Confidence: 2.96

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0418900)

Modification: Tagged | RMgm-5294

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100025

Most Similar Human Ortholog: Not available

TM-align score: 0.00 | RMSD: 0.00

Seq Identity: 0.00 | Length: / 6118

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000007174	dynein axonemal heavy chain 9
ENSG00000039139	dynein axonemal heavy chain 5
ENSG00000105877	dynein axonemal heavy chain 11
ENSG00000114841	dynein axonemal heavy chain 1
ENSG00000115423	dynein axonemal heavy chain 6
ENSG00000118997	dynein axonemal heavy chain 7
ENSG00000124721	dynein axonemal heavy chain 8
ENSG00000158486	dynein axonemal heavy chain 3
ENSG00000174844	dynein axonemal heavy chain 12
ENSG00000183914	dynein axonemal heavy chain 2
ENSG00000185842	dynein axonemal heavy chain 14
ENSG00000187240	dynein cytoplasmic 2 heavy chain 1
ENSG00000187775	dynein axonemal heavy chain 17
ENSG00000197102	dynein cytoplasmic 1 heavy chain 1
ENSG00000197653	dynein axonemal heavy chain 10
ENSG00000281935	dynein axonemal heavy chain 10

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	57	349	209	469
disruptive	128	529	357	803
missense	78	479	325	722

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	110	798	248	397
disruptive	235	1152	524	1004
missense	140	986	466	842

PlasmoDB Total SNPs: 417

Non-coding: 0 | Synonymous: 266 | Nonsynonymous: 151 | Stop Codon: 0

Protein Information

Protein Length: 6118 | Molecular Weight (kDa): 720.588

UniProt ID(s): Q8I396

PDB ID(s): None

Isoelectric Point: 6.5

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004273	Dynein heavy chain region D6 P-loop domain
InterPro	IPR013602	Dynein heavy chain, domain-2
InterPro	IPR024317	Dynein heavy chain, AAA module D4
InterPro	IPR024743	Dynein heavy chain, coiled coil stalk
InterPro	IPR026983	Dynein heavy chain
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR035699	Dynein heavy chain, hydrolytic ATP-binding dynein motor region
InterPro	IPR035706	Dynein heavy chain, ATP-binding dynein motor region
InterPro	IPR041228	Dynein heavy chain, C-terminal domain
InterPro	IPR041589	Dynein heavy chain 3, AAA+ lid domain
InterPro	IPR041658	Dynein heavy chain AAA lid domain
PFam	PF03028	Dynein heavy chain region D6 P-loop domain
PFam	PF08393	Dynein heavy chain, domain-2
PFam	PF12774	Dynein heavy chain, hydrolytic ATP-binding dynein motor region
PFam	PF12775	Dynein heavy chain, coiled coil stalk
PFam	PF12777	Dynein heavy chain, AAA module D4
PFam	PF12780	Dynein heavy chain, ATP-binding dynein motor region
PFam	PF12781	Dynein heavy chain 3, AAA+ lid domain
PFam	PF17857	Dynein heavy chain AAA lid domain
PFam	PF18198	Dynein heavy chain, C-terminal domain
PFam	PF18199
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase