Product Description: autophagy-related protein 3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000153 | cytoplasmic ubiquitin ligase complex |
| Component | GO:0005829 | cytosol |
| Function | GO:0019776 | Atg8 ligase activity |
| Process | GO:0000045 | autophagosome assembly |
| Process | GO:0000422 | autophagy of mitochondrion |
| Process | GO:0044804 | autophagy of nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | nd | nd |
| Trophozoite | expressed | nd | nd |
| Schizont | expressed | nd | nd |
| Gametocyte | expressed | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0905700.3
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.31 | MFS: -2.979 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0415700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZWA3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102211
Most Similar Human Ortholog: Q9NT62
TM-align score: 0.73 | RMSD: 2.22
Seq Identity: 0.36 | Length: 101 / 319
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000144848 | autophagy related 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 15 | 10 | 23 |
| disruptive | 8 | 21 | 16 | 39 |
| missense | 7 | 17 | 12 | 37 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 36 | 12 | 21 |
| disruptive | 14 | 45 | 27 | 79 |
| missense | 11 | 39 | 22 | 59 |
PlasmoDB Total SNPs: 96
Non-coding: 72 | Synonymous: 23 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 319 | Molecular Weight (kDa): 37.476
UniProt ID(s): A0A143ZWA3
PDB ID(s): 4EOY
Isoelectric Point: 4.32
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007135 | Autophagy-related protein 3 |
| PFam | PF03987 | Autophagy-related protein 3 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 22982544 | Structural characterization and inhibition of the Plasmodium Atg8-Atg3interaction. | Hain AU, Weltzer RR, ..., Bosch J | 10.1016/j.jsb.2012.09.001 |