About Gene List

PF3D7_0905800

Genome location: Pf3D7_09_v3:287,480..293,011(+)

Genome classification: Core

Function and Localization

Product Description: TFIIS domain-containing protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.39 0.80
Trophozoite possibly expressed 0.43 0.74
Schizont not expressed 0.15 0.91
Gametocyte not expressed 0.28 0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0905800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.173 | MFS: -2.717 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I391

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533758

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 21 65 45 90
disruptive 52 250 136 315
missense 39 211 124 269

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 30 152 71 91
disruptive 114 543 232 421
missense 70 462 186 273

PlasmoDB Total SNPs: 230

Non-coding: 94 | Synonymous: 74 | Nonsynonymous: 62 | Stop Codon: 0

Protein Information

Protein Length: 1197 | Molecular Weight (kDa): 139.988

UniProt ID(s): Q8I391

PDB ID(s): None

Isoelectric Point: 9.13

Protein Domain Annotations:

Source Family ID Description
InterPro IPR017923 Transcription factor IIS, N-terminal
InterPro IPR035441 TFIIS/LEDGF domain superfamily
PFam PF08711 Transcription factor IIS, N-terminal
Superfamily SSF47676 TFIIS/LEDGF domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108