Product Description: coatomer subunit beta, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030126 | COPI vesicle coat |
| Component | GO:0005634 | nucleus |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Process | GO:0006891 | intra-Golgi vesicle-mediated transport |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.30 | 0.85 |
| Trophozoite | possibly expressed | 0.36 | 0.77 |
| Schizont | possibly expressed | 0.28 | 0.81 |
| Gametocyte | not expressed | 0.26 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0905900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.992 | MFS: -2.733 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I390
"Best" AlphaFill ligand hit: SIW (keggin (sta), Local RMSD=0.05) with 6Y7O (Global RMSD=3.65)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101404
Most Similar Human Ortholog: A0A7I2V3G0
TM-align score: 0.97 | RMSD: 0.99
Seq Identity: 0.51 | Length: 269 / 1010
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000184432 | COPI coat complex subunit beta 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 72 | 39 | 74 |
| disruptive | 23 | 77 | 57 | 135 |
| missense | 15 | 67 | 51 | 101 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 23 | 133 | 35 | 65 |
| disruptive | 35 | 178 | 113 | 226 |
| missense | 23 | 142 | 91 | 149 |
PlasmoDB Total SNPs: 95
Non-coding: 27 | Synonymous: 43 | Nonsynonymous: 25 | Stop Codon: 0
Protein Length: 1010 | Molecular Weight (kDa): 118.245
PDB ID(s): None
Isoelectric Point: 5.22
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR006692 | Coatomer, WD associated region |
| InterPro | IPR016453 | Coatomer beta' subunit (COPB2) |
| InterPro | IPR019775 | WD40 repeat, conserved site |
| InterPro | IPR020472 | G-protein beta WD-40 repeat |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | PF00400 | WD40 repeat |
| PFam | PF04053 | Coatomer, WD associated region |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 7929113 | Yeast beta- and beta'-coat proteins (COP). Two coatomer subunits essential forendoplasmic reticulum-to-Golgi protein traffic | Duden R, Hosobuchi M, ..., Schekman R | https://pubmed.ncbi.nlm.nih.gov/7929113/ |
| 12215173 | Isolation and characterization of new Saccharomyces cerevisiae mutants perturbedin nuclear pore complex assembly | Ryan KJ, Wente SR | 10.1186/1471-2156-3-17 |
| 22761830 | Rsp5 ubiquitin ligase is required for protein trafficking in Saccharomycescerevisiae COPI mutants | Jarmoszewicz K, Lukasiak K, Riezman H, Kaminska J | 10.1371/journal.pone.0039582 |
| 8840506 | Sequence analysis of a 14.6 kb DNA fragment of Saccharomyces cerevisiaechromosome VII reveals SEC27, SSM1b, a putative S-adenosylmethionine-dependentenzyme and six new open reading frames | Escribano V, Eraso P, Portillo F, Mazon MJ | 10.1002/(SICI)1097-0061(199607)12:9<887::AID-YEA971>3.0.CO;2-D |
| 7929112 | The POX1 gene encoding peroxisomal acyl-CoA oxidase in Saccharomyces cerevisiaeis under the control of multiple regulatory elements | Wang T, Luo Y, Small GM | https://pubmed.ncbi.nlm.nih.gov/7929112/ |
| 9639310 | The Saccharomyces cerevisiae early secretion mutant tip20 is synthetic lethalwith mutants in yeast coatomer and the SNARE proteins Sec22p and Ufe1p | Frigerio G | 10.1002/(SICI)1097-0061(199805)14:7<633::AID-YEA267>3.0.CO;2-3 |
| 17101773 | Involvement of specific COPI subunits in protein sorting from the late endosometo the vacuole in yeast | Gabriely G, Kama R, Gerst JE | 10.1128/MCB.00577-06 |
| 11112704 | Cdc28-Clb mitotic kinase negatively regulates bud site assembly in the buddingyeast | Padmashree CG, Surana U | 10.1242/jcs.114.1.207 |
| 9580559 | Recycling of the yeast v-SNARE Sec22p involves COPI-proteins and the ERtransmembrane proteins Ufe1p and Sec20p | Ballensiefen W, Ossipov D, Schmitt HD | 10.1242/jcs.111.11.1507 |
| 23483999 | Aggregation of human S100A8 and S100A9 amyloidogenic proteins perturbsproteostasis in a yeast model | Eremenko E, Ben-Zvi A, Morozova-Roche LA, Raveh D | 10.1371/journal.pone.0058218 |