Product Description: vacuolar protein sorting-associated protein 46, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000815 | ESCRT III complex |
| Component | GO:0005771 | multivesicular body |
| Component | GO:0005634 | nucleus |
| Process | GO:0032509 | endosome transport via multivesicular body sorting pathway |
| Process | GO:0045324 | late endosome to vacuole transport |
| Process | GO:0015031 | protein transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.99 |
| Trophozoite | expressed | 0.25 | 0.84 |
| Schizont | expressed | 0.11 | 0.92 |
| Gametocyte | expressed | 0.22 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0906100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.135 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I388
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100996
Most Similar Human Ortholog: Q7LBR1
TM-align score: 0.58 | RMSD: 2.89
Seq Identity: 0.28 | Length: 130 / 195
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000255112 | charged multivesicular body protein 1B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 19 | 13 | 12 |
| disruptive | 2 | 2 | 7 | 15 |
| missense | 2 | 2 | 7 | 14 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 37 | 9 | 12 |
| disruptive | 3 | 23 | 18 | 44 |
| missense | 2 | 18 | 15 | 35 |
PlasmoDB Total SNPs: 133
Non-coding: 120 | Synonymous: 8 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 195 | Molecular Weight (kDa): 21.851
UniProt ID(s): Q8I388
PDB ID(s): None
Isoelectric Point: 7.39
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005024 | Snf7 family |
| PFam | PF03357 | Snf7 family |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |