About Gene List

PF3D7_0906300

Genome location: Pf3D7_09_v3:309,887..312,231(+)

Genome classification: Core

Function and Localization

Product Description: Maf-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.6.1.9 (Nucleotide diphosphatase)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus
Function GO:0047429 nucleoside-triphosphate diphosphatase activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.15 0.92
Trophozoite expressed 0.14 0.91
Schizont possibly expressed 0.03 0.98
Gametocyte expressed 0.35 0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0906300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.374 | MFS: -2.616 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I386

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
3.6.1.9 nucleotide diphosphatase ATPADPAMPGDPCTPUTPSDSUMPGSHGMPITPNaF...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_107193

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 21 25 39
disruptive 5 65 46 84
missense 4 62 46 80

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 61 27 42
disruptive 18 158 73 135
missense 14 142 66 90

PlasmoDB Total SNPs: 117

Non-coding: 73 | Synonymous: 33 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 434 | Molecular Weight (kDa): 50.772

UniProt ID(s): Q8I386

PDB ID(s): None

Isoelectric Point: 6.19

Protein Domain Annotations:

Source Family ID Description
InterPro IPR003697 Nucleoside triphosphate pyrophosphatase Maf-like protein
InterPro IPR029001 Inosine triphosphate pyrophosphatase-like
PFam PF02545 Nucleoside triphosphate pyrophosphatase Maf-like protein
Superfamily SSF52972 Inosine triphosphate pyrophosphatase-like

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596