PF3D7_0906400

Genome location: Pf3D7_09_v3:312,356..315,110(-)

Genome classification: Core

Function and Localization

Product Description: dynein intermediate light chain, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005868	cytoplasmic dynein complex
Function	GO:0045504	dynein heavy chain binding
Process	GO:0000226	microtubule cytoskeleton organization
Process	GO:0007018	microtubule-based movement

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.31	0.85
Trophozoite	not expressed	0.14	0.92
Schizont	not expressed	0.07	0.96
Gametocyte	expressed	0.85	0.56

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0906400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.863 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0414900)

Relative Growth Rate: 1.05 ± 0.09
Confidence: 6.16

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0414900)

Modification: Disrupted | RMgm-1911

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I385

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.22) with 6SU9 (Global RMSD=5.39)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102941

Most Similar Human Ortholog: B4E2E0

TM-align score: 0.67 | RMSD: 3.83

Seq Identity: 0.22 | Length: 223 / 837

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000135720	dynein cytoplasmic 1 light intermediate chain 2
ENSG00000144635	dynein cytoplasmic 1 light intermediate chain 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	45	28	58
disruptive	31	137	87	188
missense	18	123	78	161

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	101	48	75
disruptive	57	317	132	281
missense	36	271	110	200

PlasmoDB Total SNPs: 104

Non-coding: 20 | Synonymous: 56 | Nonsynonymous: 28 | Stop Codon: 0

Protein Information

Protein Length: 837 | Molecular Weight (kDa): 98.021

UniProt ID(s): Q8I385

PDB ID(s): None

Isoelectric Point: 6.72

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008467	Dynein 1 light intermediate chain
InterPro	IPR022780	Dynein family light intermediate chain
PFam	PF05783	Dynein family light intermediate chain
Superfamily	N/A	N/A