PF3D7_0906700 (LRR9)

Genome location: Pf3D7_09_v3:329,397..332,004(-)

Genome classification: Core

Function and Localization

Product Description: leucine-rich repeat protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.16	0.92
Trophozoite	expressed	0.35	0.80
Schizont	possibly expressed	0.05	0.97
Gametocyte	possibly expressed	0.27	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0906700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.819 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H521

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533256

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	33	13	47
disruptive	13	112	67	135
missense	13	111	64	129

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	64	26	43
disruptive	42	260	86	181
missense	36	237	80	124

PlasmoDB Total SNPs: 119

Non-coding: 75 | Synonymous: 22 | Nonsynonymous: 22 | Stop Codon: 0

Protein Information

Protein Length: 488 | Molecular Weight (kDa): 58.623

UniProt ID(s): C0H521, Q1L6A0

PDB ID(s): None

Isoelectric Point: 5.94

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF52058	N/A