About Gene List

PF3D7_0906800

Genome location: Pf3D7_09_v3:332,161..335,229(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.16 0.92
Trophozoite expressed 0.57 0.68
Schizont possibly expressed 0.07 0.96
Gametocyte possibly expressed 0.43 0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0906800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.165 | MFS: -3.22 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H522

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532633

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 51 24 62
disruptive 41 130 102 203
missense 28 116 93 172

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 14 94 35 71
disruptive 75 312 150 262
missense 47 253 122 185

PlasmoDB Total SNPs: 95

Non-coding: 23 | Synonymous: 40 | Nonsynonymous: 32 | Stop Codon: 0

Protein Information

Protein Length: 780 | Molecular Weight (kDa): 95.507

UniProt ID(s): C0H522

PDB ID(s): None

Isoelectric Point: 10.59

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16629662 Regulation of protein phosphatase type 1 and cell cycle progression by PfLRR1, anovel leucine-rich repeat protein of the human malaria parasite Plasmodiumfalciparum. Daher W, Browaeys E, ..., Khalife J 10.1111/j.1365-2958.2006.05119.x