PF3D7_0906910

Genome location: Pf3D7_09_v3:335,982..336,778(+)

Genome classification: Core

Function and Localization

Product Description: tubulin-specific chaperone, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.05	0.98
Trophozoite	expressed	0.18	0.89
Schizont	expressed	0.02	0.99
Gametocyte	expressed	0.50	0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0906910

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.157 | MFS: -2.854 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I381

"Best" AlphaFill ligand hit: PGO (s-1,2-propanediol, Local RMSD=0.23) with 4EGW (Global RMSD=13.08)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102852

Most Similar Human Ortholog: K7EK42

TM-align score: 0.55 | RMSD: 2.76

Seq Identity: 0.23 | Length: 122 / 262

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000105254	tubulin folding cofactor B

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	19	11	21
disruptive	6	20	8	27
missense	6	19	7	23

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	37	12	19
disruptive	12	38	30	59
missense	10	29	23	45

PlasmoDB Total SNPs: 16

Non-coding: 0 | Synonymous: 10 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 262 | Molecular Weight (kDa): 31.211

UniProt ID(s): Q8I381

PDB ID(s): None

Isoelectric Point: 5.79

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000626	Ubiquitin-like domain
InterPro	IPR000938	CAP Gly-rich domain
InterPro	IPR029071	Ubiquitin-like domain superfamily
InterPro	IPR036859	CAP Gly-rich domain superfamily
PFam	PF01302	CAP Gly-rich domain
PFam	PF14560	Ubiquitin-like domain
Superfamily	SSF54236	Ubiquitin-like domain superfamily
Superfamily	SSF74924	CAP Gly-rich domain superfamily