PF3D7_0907100

Genome location: Pf3D7_09_v3:338,140..342,542(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.11	0.94
Trophozoite	expressed	0.35	0.80
Schizont	expressed	0.17	0.90
Gametocyte	expressed	0.58	0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0907100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 4 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.977 | MFS: -2.682 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I380

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533229

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	18	92	46	111
disruptive	90	353	180	408
missense	70	321	163	355

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	29	177	65	116
disruptive	164	691	286	466
missense	123	608	242	332

PlasmoDB Total SNPs: 225

Non-coding: 12 | Synonymous: 113 | Nonsynonymous: 100 | Stop Codon: 0

Protein Information

Protein Length: 1422 | Molecular Weight (kDa): 171.073

UniProt ID(s): Q8I380

PDB ID(s): None

Isoelectric Point: 6.72

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A