PF3D7_0907200

Genome location: Pf3D7_09_v3:344,353..349,864(+)

Genome classification: Core

Function and Localization

Product Description: GTPase-activating protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0005096	GTPase activator activity
Process	GO:0090630	activation of GTPase activity
Process	GO:0006886	intracellular protein transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.77	0.65
Trophozoite	expressed	0.34	0.80
Schizont	expressed	0.53	0.68
Gametocyte	expressed	0.36	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0907200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.158 | MFS: -2.887 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0808700)

Relative Growth Rate: 0.33 ± 0.17
Confidence: 4.95

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0808700)

Modification: Disrupted | RMgm-2333

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I379

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_113395

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	19	68	32	83
disruptive	53	212	120	282
missense	40	178	108	211

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	31	137	49	73
disruptive	112	460	205	450
missense	78	354	156	224

PlasmoDB Total SNPs: 361

Non-coding: 186 | Synonymous: 106 | Nonsynonymous: 67 | Stop Codon: 2

Protein Information

Protein Length: 1133 | Molecular Weight (kDa): 134.348

UniProt ID(s): Q8I379

PDB ID(s): None

Isoelectric Point: 6.55

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000195	Rab-GTPase-TBC domain
InterPro	IPR035969	Rab-GTPase-TBC domain superfamily
PFam	PF00566	Rab-GTPase-TBC domain
Superfamily	SSF47923	Rab-GTPase-TBC domain superfamily

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104