About Gene List

PF3D7_0907300

Genome location: Pf3D7_09_v3:349,572..351,287(-)

Genome classification: Core

Function and Localization

Product Description: prefoldin-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.10 0.95
Trophozoite expressed 0.22 0.86
Schizont expressed 0.03 0.98
Gametocyte not expressed 0.13 0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0907300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.339 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0808800)

  • Relative Growth Rate: 0.01 ± 0.04
  • Confidence: 7.76

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I378

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_106089

Most Similar Human Ortholog: I3L2V7

TM-align score: 0.75 | RMSD: 0.90

Seq Identity: 0.27 | Length: 33 / 258

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000105176 URI1 prefoldin like chaperone

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 12 13 18
disruptive 4 32 42 54
missense 4 32 41 50

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 27 9 23
disruptive 8 101 37 70
missense 8 97 34 46

PlasmoDB Total SNPs: 75

Non-coding: 57 | Synonymous: 9 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 258 | Molecular Weight (kDa): 30.661

UniProt ID(s): Q8I378

PDB ID(s): None

Isoelectric Point: 6.01

Protein Domain Annotations:

Source Family ID Description
InterPro IPR004127 Prefoldin alpha-like
PFam PF02996 Prefoldin alpha-like
Superfamily SSF46579 N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104